Cotton rats and swiss albino mice were infected by various routes with a street virus strain v 308 which had been isolated from dog brain and passaged twice in mice and once in cotton rats intracerebrally infection resulted in both species by injection of 01 ml of a 10 per cent infected cotton rat brain suspension titring 10 45 in cotton rats and 10 42 in mice after intraperitoneal. Effect of rabies virus infection on gene expression in mouse brain mikhail prosniak d craig hooper bernhard dietzschold and hilary koprowski center for neurovirology department of microbiology and immunology thomas jefferson university 1020 locust street philadelphia pa 19107 6799 contributed by hilary koprowski december 28 2000. Embryonic tissues from infected eggs will have a titer of about 105 for mice ic infected chick embryos die immediately before or at time of hatching reported to be nonpathogenic in dogs used as a live virus vaccine for canine immunization as it induces immunity in dogs effect on host. A variety of molecular genetic approaches were used to study the effect of rabies virus rv infection on host gene expression in mouse brain the down regulation of gene expression was found to be a major effect of rv infection by using subtraction hybridization. Weanling female white swiss mice were exposed to challenge virus standard rabies virus and street virus isolates from various domestic and wild animals virus was given free choice as suspension or as infected mouse brain by stomach tube by single injection of suspension into the oral cavity of unanesthetized mice by repeated injection into
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