The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood transport kinetics and carrier mediated processes are described and the mechanism by which molecules can cross the barrier is discussed. The blood brain barrier bbb is a highly selective semipermeable border of endothelial cells that prevents solutes in the circulating blood from non selectively crossing into the extracellular fluid of the central nervous system where neurons reside. An introduction to the blood brain barrier excellent introduction to the phenomenology of blood brain barrier transport an understand ing of which is an obligatory first . This introduction for both researchers and clinicians is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood brain barrier may be involved. The blood brain barrier can sometimes also be broken down by injuries and infections research shows that strokes and traumatic brain injury can damage the endothelial tissue and cause the blood brain barrier to open researchers have also found that those with early signs of cognitive impairment have a breakdown of the blood brain barrier
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